A pharmacokinetic study of pyridoxal-5*-phosphate and pyrixodine
Completed
- Conditions
- onderzoek naar opname en omzetting van pyridoxal-5'-fosfaat (farmacokinetiek)Uptake and metabolism of different forms of vitamin B6
- Registration Number
- NL-OMON45563
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
healthy, adults, both male and female, aged between 20 and 50 years with normal liver and kidney function, with normal BMI (between 19 and 25), and able to come to the research laboratory on 3 specified occasions within a one week period
Exclusion Criteria
use of medication (with the exception of oral contraceptives), use of vitamin supplements during the past 6 months, detectable plasma level of pyridoxine, non-normal liver and kidney functions, BMI <19 or >25, alcohol consumption > 2 drinks/day,
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Using LC-MS-QTOF plasma concentrations of pyridoxine (PN) will be measured</p><br>
- Secondary Outcome Measures
Name Time Method <p>Plasma concentrations of other B6 vitamers and metabolites: pyridoxal (PL),<br /><br>pyridoxamine (PM), and the phosphorylated derivative pyridoxal 5*- phosphate<br /><br>(PLP) and 4-Pyridoxinic acid (PA).</p><br>