Neutrophil-to Lymphocyte and Monocyte-to-Lymphocyte Ratios in Exudative Pleural Effusion

Completed

• Conditions: Effusion

• Registration Number: NCT07003204
• Lead Sponsor: Alexandria University

Brief Summary

Exudative pleural effusion (EPE) presents a diagnostic challenge, requiring accurate biomarkers to predict outcomes and guide treatment. The neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) in pleural fluid are emerging as potential prognostic markers. We aimed to assess the diagnostic and prognostic utility of pleural fluid NLR and MLR in EPE.

Detailed Description

Pleural fluid NLR and MLR are reliable biomarkers for diagnosing malignant pleural effusion and predicting poorer survival outcomes. These ratios may be useful in clinical practice, especially in resource-limited settings, to guide decision-making in the management of pleural effusions.

Study Timeline

• Status Verified: 2025-05
• Study Start: 2025-05-11
• Primary Completion: 2025-05-25
• Study Completion: 2025-05-26
• Study First Submitted: 2025-05-26
• Study First Submitted QC: 2025-05-26
• Last Update Submitted: 2025-05-26
• Study First Posted: 2025-06-04
• Last Update Posted: 2025-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• adult patients aged 18-80 years with an EPE diagnosis confirmed by thoracentesis.

Exclusion Criteria

• Exclusion criteria included patients with a history of recent surgery, corticosteroid use, or those with mixed effusion types.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MLR and NLR measuring in pleural fluid	1 month	counting pleural fluid monocytes,lymphocytes and neutrophils

Trial Locations

Locations (1)

Chest Department -Faculty of Medicine; 🇪🇬 Alexandria, Egypt