Aortic plaques as a source of stroke - MRI based morphological and functional analysis of the aorta.

• Conditions: I63; Cerebral infarction

• Registration Number: DRKS00006234
• Lead Sponsor: niversitätsklinikum Freiburg Abteilung Neurologie und Neurophysiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06-11
• Study Completion: 2015-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Stroke patients: male and female, >49 years of age, acute stroke, cryptogenic stroke etiology after routine diagnostics (without TEE), visible ischemic lesion on cerebral imaging. 2. Control patients: male and female, >49 years of age, no history of cerebral or retianl ischemia.

Exclusion Criteria

Contraindications for MRI (ferromagentic prosthesis, cardiac pacemaker, implantable cardioverter defibrillator, insulin pump, large-scale tattoos with metalliferous pigment, artificial heart valves, pregnancy, chochlea implant, copper-bearing contraceptive coil, non-removable piercings, shell splinters or other metallic material), cardiac arrhythmias, bad general condition, no informed consent obtainable, strong claustrophobia, body weight over 130kg, refusal to participate in the study

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantitative analysis of the frequency of retrograde embolization from complex plaques of the descending aorta into the supra-aortic arteries in patients with undetermined and determined stroke etiology and controls.

Secondary Outcome Measures

Name	Time	Method
1. Quantification of plaque morphology using 3D multicontrast MRI. 2. In stroke patients: Testing the hypothesis that plaques occur primarily on locations with critically altered WSS and reduced PWV. 3. Correlation of aortic elasticity and flow reversal in the descending aorta.