MRI-derived Virtual Histology: Atherosclerotic Plaque Morphology in Relation to End-Organ Damage

Completed

• Conditions: atheroslcerosis; 10011082; 10007963; 10003216

• Registration Number: NL-OMON34848
• Lead Sponsor: Hartziekten

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 400

Inclusion Criteria

Patients with recent ( < 2 weeks) Cerebro Vascular Accident (CVA), Transient Ischemic Attack, ST-elevation Myocardial Infarction (STEMI), Non-ST-elevation Myocardial Infarction (NSTEMI)

Exclusion Criteria

Contradication for MRI or Gadolinium based contrast agent

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Comparison MRI based virtual histology of atherosclerotic plaques between<br /><br>patient groups and plaque behaviour over time.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Correlation between CEA specimen and MRI based virtual histology of carotid<br /><br>plaque.<br /><br>- Relation of biomarkers to plaque morphology and longitudinal behavior<br /><br>- Feasibility testing of new high field MRI-sequences for<br /><br>high-spatial-resolution vessel wall imaging of the aorta, carotid artery and<br /><br>coronary arteries.</p><br>