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Clinical Trials/NL-OMON47323
NL-OMON47323
Completed
Not Applicable

To study the effect of LDL-cholesterol and LDL-cholesterol lowering on hematopoietic stem cells and circulating immune cells in familial hypercholesterolemia patients. - PRIME

Academisch Medisch Centrum0 sites50 target enrollmentTBD
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Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
Academisch Medisch Centrum
Enrollment
50
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Observational invasive

Investigators

Eligibility Criteria

Inclusion Criteria

  • •\- Age \> 18 years old
  • •\- Familial hypercholesterolemia (according to Dutch Lipid network criteria)
  • •\- No previous cardiovascular events
  • •\- No current lipid lowering treatment
  • •\- LDL\-cholesterol \> 4\.9 mmol/L;Healthy controls:
  • •\- Age \>\= 18 years old
  • •\- No (previous) clinically significant health problems
  • •\- No current medication use

Exclusion Criteria

  • •1\. Malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator.
  • •2\. Chronic or recent (\<1 month) infections and/or clinical signs of acute infection and/or CRP\>10
  • •3\. Auto\-immune diseases
  • •4\. Recent or chronic immunosuppressant or antibiotic usage
  • •5\. Type I or II diabetes mellitus
  • •6\. Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.

Outcomes

Primary Outcomes

Not specified

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