Study of the effect of exercises and diet on bone and muscles in obese patients with osteosarcopenia

Not Applicable

• Conditions: Health Condition 1: E669- Obesity, unspecified

• Registration Number: CTRI/2022/07/044121
• Lead Sponsor: Indian Council of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 2 August 2022

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Age 30-60 years

-BMI>=25 Kg/m2

-Willing to give consent to participate in the study

Exclusion Criteria

-Known or recently diagnosed diabetes mellitus (HbA1c>=6.5%) or coronary heart disease

-Contraindication to aerobic exercise or progressive resistance training

-Any severe acute or chronic illness, severe end organ dysfunction, post organ transplant

-Known malignancy, HIV/ HBsAg/Anti HCV positivity

-Chronic alcohol use ( >30 g/day in men and >20 g/day in women) or any other drug abuse

-Use of any medications that may affect the muscle function or mass such as corticosteroids, anabolic steroids, protein supplements, performance enhancing medications etc.

-Pregnancy and lactation, any physical deformity or loss of extremity

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Impact of combination of nutritional intervention along with progressive resistance training and weight bearing exercise on bone mineral density and muscle mass, strength and function in osteosarcopenic individualsTimepoint: Muscle strength and function will be assessed at baseline, 3 months and at 6 months of intervention <br/ ><br>Muscle mass and bone mineral density will be assessed at baseline and at 6 months of intervention <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
Effect of weight bearing and resistance exercise training and nutritional interventions on metabolic parameters, bone resorption and bone formation biomarkers in obese osteosarcopenic individualsTimepoint: Assessment of metabolic parameters will be assessed at baseline, 3 month and at 6 month <br/ ><br>Assessment of bone resorption and bone formation biomarkers will be done at baseline and at 6 month;Prevalence and risk factors of osteosarcopenia among obese individuals.Timepoint: Risk factors of osteosarcopenia will be assessed at baseline and prevalence will be assessed when desired number of osteosarcopenia patients will be recruited over 26 months.