NCT07063550进行中（未招募）不适用
Identification of Paraneoplastic and Intratumoral Microplastics in Colorectal Cancer and Their Association Analysis With Macrogenomics and Metabolomics
Dong Peng1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2024年12月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- genomics
研究概览
简要总结
The objective of this study is to identify and characterize microplastics present in peritumoral and intratumoral tissues of colorectal cancer patients, and to investigate their associations with gut microbiome composition and metabolic profiles. By integrating microplastic analysis with metagenomic and metabolomic data, we aim to explore the potential impact of environmental microplastic exposure on tumor microenvironment alterations, microbial dysbiosis, and metabolic reprogramming in colorectal cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥18 years old) with histologically confirmed colorectal adenocarcinoma.
- •Undergoing elective radical colorectal cancer resection at the study hospital.
- •No prior chemotherapy, radiotherapy, or targeted therapy before surgery.
- •Availability of both tumor tissue and adjacent normal (peritumoral) tissue samples during surgery.
- •Willingness to provide stool and/or blood samples for metagenomic and metabolomic analysis.
- •Ability to understand the study procedures and provide written informed consent.
排除标准
- •Patients with a history of other malignancies within the past 5 years.
- •Emergency surgery due to obstruction, perforation, or bleeding.
- •Inadequate sample quality or volume for microplastic, metagenomic, or metabolomic analysis.
- •Presence of chronic inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis).
- •Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to sample collection.
- •Pregnant or breastfeeding women.
- •Refusal or inability to provide informed consent.
结局指标
主要结局
genomics
时间窗: Blood specimens were obtained within one week prior to surgery.
Genomics was tested by preoperative blood specimens.
次要结局
- metabolomics(Blood specimens were obtained within one week prior to surgery.)
研究者
Dong Peng
Principal Investigator
First Affiliated Hospital of Chongqing Medical University
研究点 (1)
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