Pilot Study of Preoperative Stereotactic Radiosurgery for Brain Metastases

Phase 2

Recruiting

• Conditions: Metastatic Cancer (brain metastases); Cancer - Any cancer; Cancer - Brain

• Registration Number: ACTRN12621001329853
• Lead Sponsor: Western Sydney Local Health District

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-29
• Last Update Posted: 15 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients aged 18 years or older.
ECOG Performance Status 0, 1 or 2.
Life expectancy at least 6 months.
Prior histopathological diagnosis of cancer other than small cell lung cancer, lymphoma, and germ cell tumours.
MRI of the brain with findings strongly suggestive of metastatic tumour(s) as assessed by the radiologist.
MRI evidence of single or multiple BM lesions amenable for SRS as discussed both by Radiation Oncologist and Neurosurgeon.

Exclusion Criteria

Not a surgical candidate per neurosurgeon's discretion.
Disseminated intracranial or leptomeningeal disease.
Neurologically unstable patients or requiring emergent surgical decompression.
Patients with Brain Metastases 5cm or larger.
Cytotoxic Chemotherapy within 7 days prior to SRS.
Anti-Vascular endothelial growth factor (VEGF) therapy within 6 weeks of SRS (risk of fatal brain haemorrhage with surgical resection).
Inability to tolerate SRS (ie, the inability to lie flat in treatment bed).
Contraindication for MRI.
Pregnancy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified