Engage: A Treatment for Late-Life Depression and Comorbid Executive/Cognitive Dysfunction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Hamilton Depression Rating Scale
研究概览
简要总结
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations. Cognitive decline is one such factor that places significant burden on older adults and can interfere with traditional mental health therapies. Engage is a behavioral treatment approach that has shown to be effective in treating late life depression. The investigators are testing the feasibility of Engage as a treatment method for late life depression in older adults with cognitive decline. The objective is to corroborate Engage as an alternative late life depression treatment method for a sub-population of older adults with cognitive decline. Cognitive decline poses a unique mental health treatment barrier that is often over looked in younger populations. With a relatively higher prevalence of cognitive decline in older adulthood, it is imperative that a feasible mental health treatment program that can be effective in the presence of cognitive decline.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 60 or older
- •Ability to read, write, and speak English
- •Located in Las Vegas or surrounding area
- •Ability to travel to UNLV campus by self or possible caregiver for regular study visits
- •Clinically significant symptoms of depression as evidenced by: 1) Scores > 5 on the Geriatric Depression Scale-Short Form (GDS-SF)
- •Mild cognitive impairment as evidenced by: 1) Scores > 18 and < 25 on the Montreal Cognitive Assessment (MoCA)
排除标准
- •Active suicidal ideation
- •History of suicide attempt(s)
- •Current symptoms of: 1) Psychosis; 2) Active substance use disorder
- •Reported history of: 1) Bipolar disorder ("manic depression"); 2) Intellectual disability
- •Currently in or scheduled to initiate individual psychotherapy to avoid treatment interference
- •Psychotropic medication permitted if dose was stable over the past 2 weeks
- •Currently living in an institutional setting (e.g., assisted living, inpatient, skilled nursing)
- •Presence of notable memory-specific cognitive deficits as evidenced by: scores < 9 on the MoCA memory subscale (rendering it difficult to participate in and track/recall events for weekly psychotherapy)
结局指标
主要结局
Hamilton Depression Rating Scale
时间窗: Assessed at Baseline, Week 6, Week 9, and Week 36 follow-up.
Measure of depressive symptoms used to assess changes across treatment from baseline to mid-treatment, to post-treatment, and follow up at 36 weeks post-baseline. Scores range from 0 - 54 with higher scores indicating worse depression.
次要结局
- Behavioral Activation for Depression Scale (BADS)(Assessed at Baseline, Week 6, Week 9, and Week 36 follow-up.)
- World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0)(Assessed at Baseline, Week 6, Week 9, and Week 36 follow-up.)
- Social Problem-Solving Inventory Revised-Short Form(Assessed at Baseline, Week 6, Week 9, and Week 36 follow-up.)
研究者
Brenna Renn
Assistant Professor
University of Nevada, Las Vegas