Olfactory Decision-making and Deprived Sleep

Not Applicable

Completed

• Conditions: Sleep Deprivation
• Interventions: Behavioral: Sleep deprivation

• Registration Number: NCT05093413
• Lead Sponsor: Northwestern University

Brief Summary

This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-14
• Study First Submitted: 2021-09-29
• Study First Submitted QC: 2021-10-13
• Study First Posted: 2021-10-26
• Primary Completion: 2022-05-19
• Study Completion: 2022-05-19
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-11
• Last Update Posted: 2022-07-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• At least 18 years old
• Fluent English speakers

Exclusion Criteria

• History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
• History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)
• Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
• Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
• Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
• Smell or taste dysfunction
• History of severe allergies requiring hospitalization for treatment
• History of severe asthma requiring hospitalization for treatment
• Habitual smoking
• History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
• Dieting or fasting
• History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
• Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
• History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
• Left-handedness
• Claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sleep deprived first; Fully slept second	Sleep deprivation	Participants will be sleep deprived during the first experimental visit and fully slept during the second experimental visit
Fully slept first; Sleep deprived second	Sleep deprivation	Participants will be fully slept during the first experimental visit and sleep deprived during the second experimental visit

Primary Outcome Measures

Name	Time	Method
Behavior an olfactory perceptual decision-making task	Up to 24 hours after the intervention	Food-like perceptual responses to binary food-nonfood odor mixtures

Secondary Outcome Measures

Name	Time	Method
Resting-state functional magnetic resonance imaging	Up to 24 hours after the intervention	Resting-state activity determined by functional magnetic resonance imaging

Trial Locations

Locations (1)

Northwestern University; 🇺🇸 Chicago, Illinois, United States