ISRCTN10803394
Completed
未知
A randomised controlled trial of the effect of intermittent energy restriction (IER) versus daily energy restriction (DER) on body fat stores and blood markers of cancer risk.
niversity Hospital of South Manchester NHS Foundation Trust0 sites26 target enrollmentJanuary 12, 2015
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Topic: Cancer
- Sponsor
- niversity Hospital of South Manchester NHS Foundation Trust
- Enrollment
- 26
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Family history of breast cancer (lifetime risk \>1 in 6\)
- •2\. Premenopausal aged \>30\-45 years
- •3\. Body mass index 30\-45 kg/m2\.
- •4\. Nonsmoker
- •5\. Sedentary (\< 40 minutes moderate exercise per week)
Exclusion Criteria
- •1\. Contradindication to MR imaging (e.g pacemaker, weight greater than 125kg)
- •2\. Already successfully losing weight.
- •3\. Pregnant or planning pregnancy over next 5 months
- •4\. Currently Breast feeding
- •5\. Eating disorder, depression or alcoholism
- •6\. Alcohol intake greater than 10g of ethanol (10 units) per week
- •7\. Comorbidity that affects liver fat stores i.e. NonAlcoholic Fatty Liver Disease, diabetes, viral hepatitis, fibrosis, Human Immunodeficiency Virus, coeliac disease
- •8\. Drug use current or within the past 6 months affecting liver fat content i.e. insulin, oral contraceptives, tamoxifen, statins, amiodarone, methotrexate, corticosteroids
- •9\. Previous or current history of cancer
- •10\. Following an incompatible therapeutic diet
Outcomes
Primary Outcomes
Not specified
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