Variation of Progesterone in IVF Cycles
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- ART Fertility Clinics LLC
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- The variation of serum progesterone around the ovulation triggering in IVF-cycles
Overview
Brief Summary
to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be carried out by several blood samples from the same patient during the day of ovulation triggering.
Detailed Description
The impact of the progesterone level at the end of the follicular phase in stimulated IVF/ICSI cycles and its effect on the pregnancy rate and oocyte quality is controversial, which arises from conflicting results in retrospective studies and meta-analyses. This study is assumed to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be carried out by several blood samples from the same patient during the day of ovulation triggering. If variation is present, the impact of variation on the developing oocyte and embryo quality will be estimated by embryo quality indicators.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •patients 18-45 years
- •BMI 18-35 kg/m2
- •Menstrual cycle length 24-35 days
- •Stimulation with rFSH or hMG
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
The variation of serum progesterone around the ovulation triggering in IVF-cycles
Time Frame: 6-8 months
the circadian secretion-pattern of progesterone during early follicular phase of normal cycling females
Secondary Outcomes
No secondary outcomes reported