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Clinical Trials/NCT01067664
NCT01067664
Completed
Not Applicable

The Effect of Serum Progesterone Levels on the Day of hCG Administration on the Probability of Pregnancy in Patients Treated by IVF Using GnRH Antagonists and Recombinant Gonadotrophins

Aristotle University Of Thessaloniki1 site in 1 country130 target enrollmentStarted: May 2009Last updated:
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ConditionsSubfertility

Overview

Phase
Not Applicable
Status
Completed
Enrollment
130
Locations
1
Primary Endpoint
Clinical pregnancy, defined as ultrasound evidence of fetal heart activity at 6-8 weeks of gestation
OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Overview

Brief Summary

This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF with the use of GnRH antagonists and recombinant gonadotrophins.

There has been evidence, that increased serum levels of progesterone are associated with a decreased probability of pregnancy after IVF.

This study will attempt to explore the role of progesterone on the outcome of IVF, by closely monitoring its levels during the late follicular phase.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to 39 Years (Adult)
Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Age \< 40 years
  • •Basal FSH \< 12 IU/L
  • •Basal P \< 1.6 ng/mL

Exclusion Criteria

  • •Presence of cystic formations at the ovaries during the basal ultrasound scan (prior the initiation of stimulation)
  • •Women with polycystic ovaries syndrome (PCOS)
  • •Women with Stage III-IV Endometriosis
  • •Women with a pathological condition of the adrenal glands

Outcomes

Primary Outcomes

Clinical pregnancy, defined as ultrasound evidence of fetal heart activity at 6-8 weeks of gestation

Time Frame: At 6-8 weeks of gestation

Secondary Outcomes

  • Pregnancy (defined as a b-hCG> 25 IU/L)(12 days after embryo transfer)

Investigators

Sponsor Class
Other

Study Sites (1)

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