Prognostic Value of Progesterone for In Vitro Fertilization (IVF) Outcome
Completed
- Conditions
- Subfertility
- Registration Number
- NCT01067664
- Lead Sponsor
- Aristotle University Of Thessaloniki
- Brief Summary
This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF with the use of GnRH antagonists and recombinant gonadotrophins.
There has been evidence, that increased serum levels of progesterone are associated with a decreased probability of pregnancy after IVF.
This study will attempt to explore the role of progesterone on the outcome of IVF, by closely monitoring its levels during the late follicular phase.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 130
Inclusion Criteria
- Age < 40 years
- Basal FSH < 12 IU/L
- Basal P < 1.6 ng/mL
Exclusion Criteria
- Presence of cystic formations at the ovaries during the basal ultrasound scan (prior the initiation of stimulation)
- Women with polycystic ovaries syndrome (PCOS)
- Women with Stage III-IV Endometriosis
- Women with a pathological condition of the adrenal glands
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical pregnancy, defined as ultrasound evidence of fetal heart activity at 6-8 weeks of gestation At 6-8 weeks of gestation
- Secondary Outcome Measures
Name Time Method Pregnancy (defined as a b-hCG> 25 IU/L) 12 days after embryo transfer
Trial Locations
- Locations (1)
Unit for Human Reproduction, 1st Dept. of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki
🇬🇷Thessaloniki, Greece