Energy expenditure in obese and overweight individuals after a low energy followed by a high energy interventio

Completed

Conditions: Obese and overweight individuals
Nutritional, Metabolic, Endocrine

Registration Number: ISRCTN11596296

Lead Sponsor: Oxford Brookes University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 16

Inclusion Criteria

1. BMI greater than 25kg/m2
2. Fat percentage higher than 22 at the body composition check
3. Aged from 18 to 60 years
4. Will not be diabetic or on a weight loss diet. At the beginning of the study, participants will complete a health-screening questionnaire and their anthropometric measurements will be taken. The health questionnaire will include questions regarding medical conditions and medication. If a participant presents a risk for disease or takes medication known to interfere with glucose metabolism, insulin signalling or energy metabolism they will be excluded from the study.

Exclusion Criteria

1. Diabetic individuals
2. History of hypoglycemia
3. Individuals on a weight loss diet
4. High blood pressure (Hypertension)
5. Low blood pressure (Hypotension)
6. Individuals who does not fulfil the inclusion criteria

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Glucose oxidation is measured using the 13C labelled glucose breath test at baseline, and then every 15 minutes for the next four hours<br>2. Metabolic rate is measured using indirect calorimetry at baseline (resting metabolic rate) at baseline and every 30 minutes for four hours.<br>3. Substrate oxidation is measured using indirect calorimetry (resting metabolic rate) at baseline and every 30 minutes for four hours.

Secondary Outcome Measures

Name	Time	Method
1. Plasma glucagon levels is measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours<br>2. Blood glucose blood levels is measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours<br>3. Insulin levels are measured from finger prick blood samples taken at baseline and every 15 minutes for the first 60 minutes after the drink and then every 30 minutes for four hours