Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis

• Conditions: Inflammatory Bowel Disease; Primary Sclerosing Cholangitis

• Registration Number: NCT02247622
• Lead Sponsor: Meir Medical Center

Brief Summary

PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.

Detailed Description

Primary sclerosing cholangitis (PSC) and colitis are chronic inflammatory disorders with malignant potential. Telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. In this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-02
• Study First Submitted: 2013-07-10
• Status Verified: 2014-09
• Primary Completion: 2014-09
• Study Completion: 2014-09
• Study First Submitted QC: 2014-09-19
• Last Update Submitted: 2014-09-19
• Study First Posted: 2014-09-25
• Last Update Posted: 2014-09-25

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• informed consent
• documented PSC and inflammatory bowel disease

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Exclusion Criteria

• under 18 years, above 80 y
• known active malignancy
• decompensated cirrhosis
• patients who cannot sign informed consent

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Telomere length	1.5 years

Secondary Outcome Measures

Name	Time	Method
number of cells with increased telomerase RNA component (TERC) expression	1.5 years

Trial Locations

Locations (1)

Meir Medical Center; 🇮🇱 Kfar Saba, Israel