NCT02247622UnknownNot Applicable
Primary Sclerosing Cholangitis Telomere Length
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Meir Medical Center
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Telomere length
Study Overview
Brief Summary
PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.
Detailed Description
Primary sclerosing cholangitis (PSC) and colitis are chronic inflammatory disorders with malignant potential. Telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. In this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •informed consent
- •documented PSC and inflammatory bowel disease
Exclusion Criteria
- •under 18 years, above 80 y
- •known active malignancy
- •decompensated cirrhosis
- •patients who cannot sign informed consent
Outcomes
Primary Outcomes
Telomere length
Time Frame: 1.5 years
Secondary Outcomes
- number of cells with increased telomerase RNA component (TERC) expression(1.5 years)
Investigators
ido laish
Md.
Meir Medical Center
Study Sites (1)
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