Restoration of cardiac function and regional pulmonary blood flow in chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy assessed during exercise by magnetic resonance imaging

• Conditions: 10014523; 10019280; chronic pulmonary embolism; chronic thromboembolic pulmonary hypertension; 10037454

• Registration Number: NL-OMON30973
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Part one study: Operable CTEPH
Part two study: Patients after PEA with near-normalized pulmonary artery pressure

Exclusion Criteria

Renal insufficiency (creatinin >115 umol/l)
Part one study: generally accepted contraindications for MRI
Part two study: also: residual pulmonary hypertension (mean PAP>30 mmHg)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Level of restoration of right ventricle stroke volume response during<br /><br>exercise<br /><br>2) Level of restoration of regional blood flow after PEA</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Relationship between the level of restoration of cardiac function and the<br /><br>level of restoration of regional blood flow<br /><br>2) Relationship between the level of restoration of cardiac function and the<br /><br>directly postoperative observed hemodynamic improvement.</p><br>