Longitudinal Pattern of Streptococcus Pneumoniae Nasopharyngeal Carriage and Antimicrobial Susceptibility in Healthy Children Aged Less Then 5 Years, in the Area of Milan and Surroundings, Lombardy, Italy.

• Conditions: Streptococcus Pneumoniae Nasopharyngeal Carriage

• Registration Number: NCT01443793
• Lead Sponsor: University of Milan

Brief Summary

The objective of this active surveillance study is to make available crucial data about epidemiology, serotype distribution, and longitudinal pattern of antibiotic susceptibility of nasopharyngeal strains of Streptococcus pneumoniae carried in the population of healthy children aged less than years and living in the area of Milan and surroundings, Lombardy, Italy.

* To estimate the nasopharyngeal carriage rate and longitudinal pattern of Streptococcus pneumoniae in healthy children aged less than 5 years living in the area of Milan, Italy;

* To describe the circulation of antimicrobial non-susceptible Streptococcus pneumoniae strains in healthy children aged less than 5 years

Secondary objectives:

* To describe the nasopharyngeal carriage distribution of Streptococcus pneumoniae strains in healthy subjects less than 5 years old;

* To examine the role of risk factors in the Streptococcus pneumoniae carriage rate in healthy children;

* • To evaluate the possible impact of vaccination policy in the referenced population.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2011-09-28
• Study First Submitted QC: 2011-09-28
• Study First Posted: 2011-09-30
• Status Verified: 2011-10
• Last Update Submitted: 2011-10-02
• Last Update Posted: 2011-10-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1300

Inclusion Criteria

• To estimate the nasopharyngeal carriage rate and longitudinal pattern of Streptococcus pneumoniae in healthy children aged less than 5 years living in the area of Milan, Italy;
• To describe the circulation of antimicrobial non-susceptible Streptococcus pneumoniae strains in healthy children aged less than5 years

Exclusion Criteria

• To describe the nasopharyngeal carriage distribution of Streptococcus pneumoniae strains in healthy subjects less than 5 years old;
• To examine the role of risk factors in the Streptococcus pneumoniae carriage rate in healthy children;
• To evaluate the possible impact of vaccination policy in the referenced population..

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• circulation of antimicrobial non-susceptible Streptococcus pneumoniae strains in healthy children aged less than 5 years	1 year

Secondary Outcome Measures

Name	Time	Method
• the nasopharyngeal carriage distribution of Streptococcus pneumoniae strains in healthy subjects less than 5 years old;	1 year
• the role of risk factors in the Streptococcus pneumoniae carriage rate in healthy children;	1 year
• the possible impact of vaccination policy in the referenced population	1 year

Trial Locations

Locations (1)

AO L.Sacco; 🇮🇹 Milano, Italy