Positron Emission Tomography (PET) With 3,4-dihydroxy-6-18F-fluoro-L-enylalanine (18F-FDOPA) Study
- Conditions
- Cancer (High-grace Glioma)
- Registration Number
- NCT01248754
- Lead Sponsor
- Alan Nichol
- Brief Summary
The 18F-FDOPA PET tracer is an amino acid analogue that can be used to visualize high-grade glioma not clearly identified on diagnostic MRI. Use of 18F-FDOPA PET will permit neurosurgeons to achieve a complete resection more frequently.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Contrast-enhancing mass on diagnostic brain CT or MRI strongly suggesting a diagnosis of WHO grade III or IV glioma
- Karnofsky Performance status (KPS) ≥ 70
- Age ≥18 years
- Subject is able to understand and consent to study
- Glomerular filtration rate (GFR) ≥ 45 ml/minute
- Indication for urgent craniotomy to relieve mass effect
- Only stereotactic biopsy indicated because tumour is located in eloquent brain.
- The enhancement on the T1 MRI sequence involves or abuts the basal ganglia
- Previous intracranial malignancy or any invasive malignancy unless free of disease > 5 years
- Prior cranial irradiation
- Contra-indications to systemic radiation exposure: pregnancy or breast feeding
- Subject exceeds the weight limit of the PET scanner bed (204.5 kg)
- Subjects taking medication such as Levodopa for the treatment of Parkinson's Disease
- Allergies or other contraindication to CT contrast or MRI contrast
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method The proportion of subjects that have a complete resection of the volume of 18F-FDOPA PET tracer on their postoperative 18F-FDOPA PET scan. Less than 72 hours postoperatively
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (3)
Lions Gate Hospital
🇨🇦North Vancouver, British Columbia, Canada
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
BC Cancer Agency
🇨🇦Vancouver, British Columbia, Canada
Lions Gate Hospital🇨🇦North Vancouver, British Columbia, Canada