Social feedback and emotion regulation in borderline personality disorder

Recruiting

Conditions: affective instabilitty
10034726
borderline personality disorder

Registration Number: NL-OMON39937

Lead Sponsor: niversiteit Leiden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 76

Inclusion Criteria

Participants with BPD
1) All BPD participants in this study will be recruited from the participants in the BPD treatment study (P12.227). The diagnosis of BPD will be confirmed by a structured diagnostic interview already assessed in that study. The same inclusion criteria will be adopted, except for additional fMRI requirements (see the protocol for details).
2) After being fully informed about the study and the risks of participation informed consent should be signed.;Healthy participants
1) Participants are able to understand the given information
2) After being fully informed about the study and the risks of participation informed consent should be signed
3) Participants are in excellent mental and physical condition
4) Age: > 18 yrs, < 55, and matched with BPD patients

Exclusion Criteria

Participants with BPD
1) Alcohol or drugs abuse
2) The use of benzodiazepines more than the equivalent of 20 mg of oxazepam or any antipsychotic medication (Stable use of SSRI*s is allowed)
3) Metal implants, surgical clips, pacemakers, and left-handedness.;Healthy participants
1) History of psychiatric problems by the MINI
2) Somatic illnesses
3) Alcohol or drug dependence by the MINI
4) Regular medications
5) Metal implants, surgical clips, pacemakers, and left-handedness

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Behavioural measures: self-report ratings on state self-esteem and mood states<br /><br>during the tasks (evaluative social feedback and script-driven emotional<br /><br>imagination. Imaging): Blood-Oxygen-Level Dependent (BOLD) response during<br /><br>these tasks; BOLD response during rest and after the evaluative social feedback<br /><br>task (functional connectivity).</p><br>

Secondary Outcome Measures