Changes of Tear-film Lipid Layer Thickness and Ocular Aberration After Treatment of Meibomian Gland Dysfunction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Changes of tear-film lipid layer thickness after treatment of meibomian gland dysfunction
研究概览
简要总结
In this study, investigator aim to evaluate the changes of tear-film lipid layer thickness and ocular aberration after treatment of meibomian gland dysfunction. In case of stage 3 or 4 meibomian gland dysfunction, participants will be treated using conventional treatment modalities. Before treatment and after 1 and 2 months of treatment, a variety of ophthalmic examination, tear-film lipid layer thickness, and ocular aberration are going to measured and compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age over 19 years old, with moderate to severe Meibomian gland dysfunction.
排除标准
- •patients with history of previous ocular or intraocular surgery
- •ocular infection, non dry eye ocular inflammation, ocular allergy, autoimmune disease
- •history of intolerance or hypersensitivity to any component of the study medications
- •wearing contact lenses during the study period, presence of current punctal occlusion
- •pregnancy, lactating women, and children
研究组 & 干预措施
moderate to severe meibomian gland dysfunction
干预措施: Treatment of Meibomian gland dysfunction (Drug)
结局指标
主要结局
Changes of tear-film lipid layer thickness after treatment of meibomian gland dysfunction
时间窗: 1 and 2 months after treatment of meibomian gland dysfunction
Changes of ocular aberration after treatment of meibomian gland dysfunction
时间窗: 1 and 2 months after treatment of meibomian gland dysfunction
ocular parameters measured by Ray-tracing wavefront aberrometers (i-Trace, Tracey technologies , Texas ,USA)
次要结局
- Meibomian quality(1 and 2 months after treatment of meibomian gland dysfunction)
- Meibomian gland abnormality(1 and 2 months after treatment of meibomian gland dysfunction)
- Corneal erosion grade(oxford score)(1 and 2 months after treatment of meibomian gland dysfunction)
- OSDI(ocular surface disease index)(1 and 2 months after treatment of meibomian gland dysfunction)
- BUT(tear break-up time)(1 and 2 months after treatment of meibomian gland dysfunction)