Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Tear Lipid Layer thickness measurement with a LipiView interferometer
研究概览
简要总结
In this study, the investigators aim to determine the effects of age, sex, history of ocular surgery and contact lens use, and ocular surface and meibomian gland parameters on the lipid layer thickness (LLT) in normal subjects and patients with dry eye syndrome. Patients with dry eye syndrome and subjects with a healthy ocular surface will be enrolled. All participant will underwent LLT measurement with a LipiView interferometer, tear meniscus height measurement using optical coherence tomography, tear film break-up time (TBUT) determination, corneal and conjunctival staining, Schirmer's test, examination of the lid margins and meibomian glands, and assessment using the Ocular Surface Disease Index(OSDI) questionnaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 19 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age over 19 years old, Patients with dry eye syndrome and normal subjects
排除标准
- •patients less than 18 years of age and patients with histories of ocular surgery within 3 months; ocular injury; and ocular diseases such as ocular infection, allergy, and autoimmune disease; and patients with the use of a punctal plug or topical ocular medications other than artificial tears.
- •Patients who used artificial tears were instructed not to apply them for at least 12 hours 99 before the examinations
结局指标
主要结局
Tear Lipid Layer thickness measurement with a LipiView interferometer
时间窗: 1 day
次要结局
- Corneal and conjunctival erosion grade(oxford score)(1 day)
- tear film break-up time (TBUT)(1 day)
- Ocular Surface Disease Index(OSDI) questionnaire(1 day)
- Schirmer's test (lacrimal secretion test)(1 day)
- evaluation of the score of lid margins and meibomian glands(1 day)
- tear meniscus height measurement using optical coherence tomography(1 day)