Effects of Tai Chi Chuan With Different Doses on Cognitive Function in Elderly Patients With Mild Cognitive Impairment
Not Applicable
Not yet recruiting
- Conditions
- Mild Cognitive Impairment
- Interventions
- Behavioral: Tai Chi Chuan （dose 6）Behavioral: Tai Chi Chuan （dose 1）Behavioral: Tai Chi Chuan （dose 3）Behavioral: Tai Chi Chuan （dose 7）Behavioral: Tai Chi Chuan （dose 2）Behavioral: Tai Chi Chuan （dose 9）Behavioral: Tai Chi Chuan （dose 4）Behavioral: Tai Chi Chuan （dose 5）Behavioral: Tai Chi Chuan （dose 8）
- Registration Number
- NCT06372535
- Lead Sponsor
- Lidian Chen
- Brief Summary
To determine the impact of Tai Chi Chuan with different exercise volume on cognitive function in elderly patients with mild cognitive impairment.
- Detailed Description
Taking MCI as a potential gateway, early intervention to delay the occurrence of dementia has become an important consensus in this field. Exercise is an important means to improve cognitive function in MCI, but the effect of exercise is influenced by the dosage. Tai Chi Chuan, is a moderate intensity aerobic exercise. Previous studies by our team and others had confirmed its effect on cognitive function in MCI. However, the dose parameters of Tai Chi Chuan exercise varied in these studies, and the dose-response relationship is still unclear. The purpose of this study is to explore the dose-response relationship between different volume of Tai Chi Chuan exercise and cognitive function（global cognition and cognition of subdomains）in elderly MCI patients.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 540
Inclusion Criteria
- Presence of mild cognitive impairment, not demented;
- Age ≥ 60 years old;
- Informed consent and voluntary participation.
Exclusion Criteria
- Geriatric Depression Scale score ≥ 9 points
- Cognitive impairment caused by other reasons, taking drugs, poisoning, etc;
- Suffer from severe musculoskeletal system diseases and other contraindications to exercise and are not suitable for Tai Chi training, such as those who suffer from stroke, Parkinson's disease, and have a history of lower limb arthritis, hip and knee joint replacement, etc;
- Patients with severe heart, liver, kidney failure, malignant tumors, and other major diseases;
- Individuals with visual/auditory impairments, writing/reading impairments, illiteracy, etc. that affect training and evaluation;
- Individuals with uncontrolled hypertension (systolic blood pressure greater than 160mmHg or diastolic blood pressure greater than 100mmHg after medication);
- Participating in other experiments that influence this study;
- Engaged in regular exercise in the last three months (at least 3 times a week, at least 20 minutes of regular exercise each time.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tai Chi Chuan Group6 Tai Chi Chuan （dose 6） Tai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks. Tai Chi Chuan Group1 Tai Chi Chuan （dose 1） Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 8 weeks. Tai Chi Chuan Group3 Tai Chi Chuan （dose 3） Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 24 weeks. Tai Chi Chuan Group7 Tai Chi Chuan （dose 7） Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 8 weeks. Tai Chi Chuan Group2 Tai Chi Chuan （dose 2） Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 16 weeks. Tai Chi Chuan Group9 Tai Chi Chuan （dose 9） Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 24 weeks. Tai Chi Chuan Group4 Tai Chi Chuan （dose 4） Tai Chi Chuan 1 hour/session, 5 sessions/week for 8 weeks. Tai Chi Chuan Group5 Tai Chi Chuan （dose 5） Tai Chi Chuan 1 hour/session, 5 sessions/week for 16 weeks. Tai Chi Chuan Group8 Tai Chi Chuan （dose 8） Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 16 weeks.
- Primary Outcome Measures
Name Time Method Montreal Cognitive Assessment 8 weeks, 16 weeks, 24 weeks Global cognition
- Secondary Outcome Measures
Name Time Method Montreal Cognitive Assessment 52 weeks Global cognition
Trial Making Test part B 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks Executive function
Wechsler Memory Scale 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks Memory function
Rey-Osterrieth complex graphics test 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks Rey-Osterrieth complex graphics test
Rey Auditory Verbal Learning Test 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks Episodic memory
Digital Symbol test 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks Attention
Stroop color word test 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks Processing speed
Boston naming test 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks Verbal fluency