Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
- Conditions
- Mild Cognitive Impairment
- Interventions
- Behavioral: The Go for Exercise & Healthy Aging Project
- Registration Number
- NCT04070703
- Lead Sponsor
- Oregon Research Institute
- Brief Summary
To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.
- Detailed Description
The primary aim of the study is to determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health, relative to a standard Tai Ji Quan intervention and an exercise stretching control, in improving global cognitive function and dual-task ability among community-dwelling older adults with amnestic mild cognitive impairment.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 332
- complaint of memory loss
- clinical dementia rating (CDR) scale score ≤0.5
- having normal general cognitive function screened, with MMSE ≥24
- capable of exercising safely, as determined by a healthcare provider
- willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up
- having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure
- participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cognitively enhanced Tai Ji Quan The Go for Exercise & Healthy Aging Project Participants in this arm will exercise a series of Tai Ji Quan-based movements with configurations that are specifically designed for older adults to improve cognitive function, dual-task ability, strength/balance, and mobility. Standard Tai Ji Quan The Go for Exercise & Healthy Aging Project Serving as an active comparison arm, participants in this intervention will exercise a series of Tai Ji Quan-based movements that are specifically designed for older adults to improve strength/balance, cognitive function, and mobility. Stretching The Go for Exercise & Healthy Aging Project Serving as a control arm, participants in this intervention will engage in a series of light exercise activities consisting of breathing, stretching, and body relaxation.
- Primary Outcome Measures
Name Time Method Montreal Cognitive Assessment baseline, 6 months Change in global cognitive function from baseline to 24 weeks
gait under a dual-task condition - walking with no cognitive task, walking with a concurrent cognitive task baseline, 6 months Change in dual-task ability from baseline to 24 weeks
- Secondary Outcome Measures
Name Time Method Clinical Dementia Rating baseline, 6 months Change in cognitive decline from baseline to 24 weeks
Computerized cognitive battery tests baseline, 6 months Change in domain-specific cognitive function from baseline to 24 weeks
Paper-and-pencil domain-specific cognitive battery tests baseline, 6 months Change in domain-specific cognitive function from baseline to 24 weeks
Physical performance - Functional Reach; Short Physical Performance Battery baseline, 6 months Change in physical performance from baseline to 24 weeks
Trial Locations
- Locations (1)
Oregon Research Institute
🇺🇸Eugene, Oregon, United States