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Clinical Trials/NCT03836118
NCT03836118
Completed
Not Applicable

Retrospective Evaluation of Clinical Predictors of Pregnancy and Live-birth After Homologous Intrauterine Insemination

Istituto Clinico Humanitas1 site in 1 country2,970 target enrollmentJanuary 1, 1997
ConditionsInfertility

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Infertility
Sponsor
Istituto Clinico Humanitas
Enrollment
2970
Locations
1
Primary Endpoint
live-birth rate (LBR)
Status
Completed
Last Updated
7 years ago

Overview

Brief Summary

Multiple studies have reported on the impact of factors such as female age, duration of infertility, type of infertility, hormone levels (i.e. AMH, FSH, estradiol, progesterone), use of different ovarian stimulation protocols, timing/induction of ovulation, number of pre-ovulatory follicles, endometrial thickness by the time of ovulation, sperm parameters (i.e. concentration, progressive motility, morphology, total motile sperm count [TMSC], inseminating motile count [IMC]) and sperm washing procedures. Also the influence of body mass index and smoking on IUI outcome have been studied before. However, results on the predictive value of these parameters remain highly contradictory. The aim of the study is to examine the value of different variables in the prediction of IUI success to develop a clinically useful predictive model of pregnancy and live birth.

Registry
clinicaltrials.gov
Start Date
January 1, 1997
End Date
August 31, 2018
Last Updated
7 years ago
Study Type
Observational
Sex
Female

Investigators

Sponsor
Istituto Clinico Humanitas
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • couples had been diagnosed with infertility according to WHO definition (failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse)
  • at least one permeable tube
  • a motile sperm concentration post treatment of 1×106/mL on the day of the semen analysis

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

live-birth rate (LBR)

Time Frame: 1997 - 2017

clinical pregnancy rate (CPR)

Time Frame: 1997-2017

Study Sites (1)

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