Estrogen Hormone Protocol

Phase 3

Completed

• Conditions: Alzheimer Disease

• Registration Number: NCT00000177
• Lead Sponsor: National Institute on Aging (NIA)

Brief Summary

Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen. Because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for Alzheimer's disease. The enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. Several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with Alzheimer's disease who take estrogen.

Detailed Description

Not available

Study Timeline

• Study Start: 1995-10
• Primary Completion: 1999-01
• Study Completion: 1999-01
• Study First Submitted: 1999-10-29
• Study First Submitted QC: 1999-10-29
• Study First Posted: 1999-11-01
• Status Verified: 2009-09
• Last Update Submitted: 2009-12-10
• Last Update Posted: 2009-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

• Women with a diagnosis of Alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health.

Exclusion Criteria

• Patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Trial Locations

Locations (25)

University of Alabama, Birmingham; 🇺🇸 Birmingham, Alabama, United States

University of California, San Diego; 🇺🇸 San Diego, California, United States

Mayo Clinic Jacksonville; 🇺🇸 Jacksonville, Florida, United States

University of South Florida; 🇺🇸 Tampa, Florida, United States

Emory University; 🇺🇸 Atlanta, Georgia, United States

Rush Presbyterian St. Luke's Medical Center; 🇺🇸 Chicago, Illinois, United States

Southern Illinois University; 🇺🇸 Springfield, Illinois, United States

Indiana University Medical Center; 🇺🇸 Indianapolis, Indiana, United States

University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States

University of Kentucky; 🇺🇸 Lexington, Kentucky, United States

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