Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition
- Registration Number
- NCT01395381
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
The benefit of anti-worm therapy as part of the case management of severe acute malnutrition (SAM) in the outpatient setting has not previously been studied. This study will compare recovery rates of children with SAM treated in the community with locally-produced ready-to-use therapeutic food (RUTF) with and without prescribed albendazole as part of their case management.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- 12-59 months old
- Kwashiorkor and/or Marasmus
- Qualified for home-based therapeutic feeding with RUTF
Exclusion Criteria
- Obvious congenital or other malformation that makes child a poor candidate for feeding with RUTF
- Unable to consume test-dose of RUTF in clinic
- Parent refusal to participate and return for follow-up
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - Albendazole Albendazole -
- Primary Outcome Measures
Name Time Method nutritional recovery 12 weeks Weight-for-Height Z-score (WHZ) \> -2 without bipedal pitting edema
mortality 12 weeks
- Secondary Outcome Measures
Name Time Method malnutrition relapse 6 months acute malnutrition, either moderate (WHZ \< -2) or severe (WHZ \< -3 and/or bipedal pitting edema)
height and weight gain 6 months
Trial Locations
- Locations (1)
St. Louis Nutrition Project
🇲🇼Blantyre, Malawi