Comparative evaluation of Herbal, Chlorine dioxide and Probiotic based mouthwashes on reduction of biofilm in 6-12 years old children: An Invivo study
概览
- 阶段
- Post Marketing Surveillance
- 状态
- 已完成
- 发起方
- Dr. Shaik Salma
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Sillness and Loe Plaque Index
概览
简要总结
Oral hygiene practices that intervene with plaque formation play a crucial role in preventing dental caries. Raising concerns of toxicity with conventional mouthwash usage led to the search for biologically safe mouth rinsing agents in children. The present study aims to evaluate the efficacy of Herbal (Botanical Oral rinse) and Stabilized Chlorine Dioxide (ClO2) mouth wash in beneficially altering the oral ecological niche in children aged 6-12 years. Prior to intervention, the plaque accumulation will be assessed using Sillness and Loe Plaque index and unstimulated saliva samples will be collected to quantify S. mutans as a baseline data. The children will then be instructed to rinse the allocated mouthwash once daily for 60 sec for 14 days and fill the supplied checklist . The assessment of all the parameters will be repeated after 14 days of intervention and the values will be subjected to statistical analysis.
研究设计
- 研究类型
- Pms
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 6.00 Year(s) 至 12.00 Year(s)(—)
- 性别
- All
入选标准
- •Children within the age range of 6-12 years.
- •Children with DMFT score ≤ 2 3)Children with no history of antibiotic or probiotics in any form in the past three months.
排除标准
- •Medically compromised children 2)Children with history of systemic allergies and diseases.
- •Children using any prosthodontic/orthodontic appliance.
结局指标
主要结局
Sillness and Loe Plaque Index
时间窗: Pre evaluation(baseline plaque scores will be assessed) After 14 days of intervention, post evaluation of plaque scores will be assessed.
次要结局
- s.mutans bacterial load(pre evaluation(baseline s.mutans count on Day 0) & After 14 days of intervention, post evaluation of s.mutans count (Day 15))
研究者
Dr Shaik Salma
GITAM Dental College and Hospital