Linking the Change in Decision-making After Sleep Restriction to the Restorative Function of Sleep
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sleep Restriction
- Sponsor
- Christian Baumann
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- risk-premium
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of this project is to investigate whether enhancing sleep intensity locally in the prefrontal cortex (PFC) can counteract a deterioration of cognitive control and therefore the previously described increase in risk seeking during chronic sleep restriction. To this end, a controlled, counter-balanced study, consisting of two weeks of sleep restriction will be performed. During one of the sleep restriction weeks, sleep intensity in the PFC will be non-invasively enhanced by acoustic stimulation of slow waves during sleep.
Investigators
Christian Baumann
Prof. Dr. med.
University of Zurich
Eligibility Criteria
Inclusion Criteria
- •Age between 18-21 years or 26-30 years,
- •Right-handedness,
- •Good general health,
- •Good understanding of German language (as all information is provided in German)
- •Signed Informed Consent after being informed.
Exclusion Criteria
- •Contraindications on ethical grounds,
- •Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc),
- •Known or suspected non-compliance, drug or alcohol abuse (\> 5dl wine/ \>1l beer daily),
- •Regular medication intake,
- •Enrolment into a clinical trial within last 4 weeks,
- •Diseases or lesions of the nervous system (acute or residual included neurological and psychiatric diseases),
- •Sleep disorders (e.g. Insomnia, sleep apnoea, restless leg syndrome, narcolepsy, etc.),
- •Sleep complaints in general or excessive daytime sleepiness (Pittsburgh Sleep Quality Index \> 5; Epworth Sleepiness Scale ≥ 11),
- •Irregular sleep-wake rhythm (e.g. shift working),
- •Long (\> 10 hours per night) or short sleepers (\< 7 hours per night),
Outcomes
Primary Outcomes
risk-premium
Time Frame: comparison of change from baseline after 7 nights of sleep restriction with acoustic stimulation to change from baseline after 7 nights of sleep restriction without acoustic stimulation
risk-preference (i.e. risk premium assessed with the risk Task as described in Maric et al. 2017 Ann Neurol) after chronic sleep restriction with and without acoustic Stimulation will be quantified by the risk-premium derived from the choices made in the risk-task as described in Maric et al. 2017 Ann Neurol.
Secondary Outcomes
- confidence(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- high-density electroencephalography (hdEEG) marker of sleep pressure(assessed during first and last sleep restriction nights in comparison to baseline values)
- brain metabolites(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- impulsivity(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- Effort in inhibitory control performance(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- vigilance measures(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- overconfidence(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- Ocular inhibitory control performance(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- Excessive daytime sleepiness(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- deception willingness(before to after 7 nights of sleep restriction with and without acoustic stimulation)
- Motor inhibitory control performance(before to after 7 nights of sleep restriction with and without acoustic stimulation)