Decision-making After Sleep Restriction
- Conditions
- Sleep Restriction
- Interventions
- Behavioral: Sleep restrictionOther: Acoustic stimulation
- Registration Number
- NCT03692962
- Lead Sponsor
- Christian Baumann
- Brief Summary
The aim of this project is to investigate whether enhancing sleep intensity locally in the prefrontal cortex (PFC) can counteract a deterioration of cognitive control and therefore the previously described increase in risk seeking during chronic sleep restriction. To this end, a controlled, counter-balanced study, consisting of two weeks of sleep restriction will be performed. During one of the sleep restriction weeks, sleep intensity in the PFC will be non-invasively enhanced by acoustic stimulation of slow waves during sleep.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 28
- Age between 18-21 years or 26-30 years,
- Right-handedness,
- Good general health,
- Good understanding of German language (as all information is provided in German)
- Signed Informed Consent after being informed.
- Contraindications on ethical grounds,
- Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc),
- Known or suspected non-compliance, drug or alcohol abuse (> 5dl wine/ >1l beer daily),
- Regular medication intake,
- Enrolment into a clinical trial within last 4 weeks,
- Diseases or lesions of the nervous system (acute or residual included neurological and psychiatric diseases),
- Sleep disorders (e.g. Insomnia, sleep apnoea, restless leg syndrome, narcolepsy, etc.),
- Sleep complaints in general or excessive daytime sleepiness (Pittsburgh Sleep Quality Index > 5; Epworth Sleepiness Scale ≥ 11),
- Irregular sleep-wake rhythm (e.g. shift working),
- Long (> 10 hours per night) or short sleepers (< 7 hours per night),
- Sleep efficiency < 80% in screening night,
- Travelling with time lag less than 1 month ago (or planning to do so within 1 month prior to or during the study),
- > 5 drinks or food items containing caffeine per day,
- > 5 cigarettes per day,
- Body Mass Index < 19 or > 30 kg/m2,
- Skin allergy or very sensitive skin
- Student of one of the following subjects: Mathematics, Physics, Computer Science, Economics, or Psychology (since students of these subjects have profound knowledge of probability calculations, which could interfere with our measurements in decision-making).
- Red-Green Colour-Blindness (as the Risk Task requires the distinction between red and green),
- History of claustrophobia,
- Known hearing disorder (as acoustic stimuli will be applied during sleep),
- Magnetic Resonance (MR) contraindication (such as pacemaker, implanted pumps, shrapnel, etc.; full MR Screening form will be filled out).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Sleep restriction without acoustic stimulation Sleep restriction - Sleep restriction with acoustic stimulation Sleep restriction - Sleep restriction with acoustic stimulation Acoustic stimulation -
- Primary Outcome Measures
Name Time Method risk-premium comparison of change from baseline after 7 nights of sleep restriction with acoustic stimulation to change from baseline after 7 nights of sleep restriction without acoustic stimulation risk-preference (i.e. risk premium assessed with the risk Task as described in Maric et al. 2017 Ann Neurol) after chronic sleep restriction with and without acoustic Stimulation will be quantified by the risk-premium derived from the choices made in the risk-task as described in Maric et al. 2017 Ann Neurol.
- Secondary Outcome Measures
Name Time Method confidence before to after 7 nights of sleep restriction with and without acoustic stimulation overconfidence measured by an incentivised procedure that elicits the certainity equivalent of a bet based on Performance in a quiz (cf. Murad et al. 2016 J Risk Uncertain)
brain metabolites before to after 7 nights of sleep restriction with and without acoustic stimulation Glutamate and gamma-aminobutyric acid (GABA) concentration in the right prefrontal Cortex assessed by magnetic resonance (MR) spectroscopy
impulsivity before to after 7 nights of sleep restriction with and without acoustic stimulation impulsivity as measured by an intertemporal choice Task.
high-density electroencephalography (hdEEG) marker of sleep pressure assessed during first and last sleep restriction nights in comparison to baseline values Slow wave activity (SWA) assessed by hd-EEG with 128 electrodes
Effort in inhibitory control performance before to after 7 nights of sleep restriction with and without acoustic stimulation Pupil response (i.e. dilation) during a simple Go/No-Go Task.
vigilance measures before to after 7 nights of sleep restriction with and without acoustic stimulation Performance impairments in the psychomotor-vigilance task
overconfidence before to after 7 nights of sleep restriction with and without acoustic stimulation overconfidence measured by an incentivised procedure that elicits the certainity equivalent of a bet based on Performance in a quiz (cf. Murad et al. 2016 J Risk Uncertain)
Ocular inhibitory control performance before to after 7 nights of sleep restriction with and without acoustic stimulation Ocular inhibitory control Performance measured by the Anti-Saccade Task.
Excessive daytime sleepiness before to after 7 nights of sleep restriction with and without acoustic stimulation Excessive daytime sleepiness assessed by the Epworth sleepiness scale and the Stanford Sleepiness Scale.
deception willingness before to after 7 nights of sleep restriction with and without acoustic stimulation deception willingness measured by the willingness to deception of outcome in a card game with binary outcome (win and loss)
Motor inhibitory control performance before to after 7 nights of sleep restriction with and without acoustic stimulation inhibitory control performance measured by the stop-signal-task.
Trial Locations
- Locations (1)
University Hospital Zurich
🇨🇭Zürich, Zurich, Switzerland