Transthoracic echocardiography and ophthalmic artery Doppler measurements in pregnant wome

Not Applicable

• Conditions: Hypertension; Preeclampsia; Human immunodeficiency virus (HIV); Pregnancy; Cardiovascular - Hypertension; Infection - Acquired immune deficiency syndrome (AIDS / HIV); Reproductive Health and Childbirth - Fetal medicine and complications of pregnancy

• Registration Number: ACTRN12613000992707
• Lead Sponsor: niversity of Cape Town

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-09-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: Female
• Target Recruitment: 230

Inclusion Criteria

Healthy term and preterm pregnant women
Women with term and preterm preeclampsia
Term pregnant women with HIV
Pregnant women with haemodynamic instability

Exclusion Criteria

current administration of vasoactive drugs including salbutamol and thyroxine, pre-existing or gestational diabetes, known cardiac disease including pre-existing or gestational hypertension, multiple pregnancy, a known uterine abnormality or abnormal placentation, any woman in labour, inability to consent to the study.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiac output measured by transthoracic echocardiography[after 5 minutes of rest or at time of diagnosis of preeclampsia]

Secondary Outcome Measures

Name	Time	Method
Systolic and diastolic function and cardiac structure including fractional shortening, ejection fraction, mitral valve E and A velocities, tissue Doppler velocities, isovolumetric relaxation and contraction times, left atrial size, left ventricular end diastolic size, left ventricular mass measured by transthoracic echocardiography[after 5 minutes rest or at the time of diagnosis of preeclampsia]