ISRCTN17516192进行中（未招募）2 期
A single-centre, randomised, open label, blinded end-point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 600 mg/kg) in patients with paracetamol overdose (HiSNAP)
Accord (United Kingdom)0 个研究点目标入组 90 人开始时间: 2023年11月21日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Single acute paracetamol overdose presenting to hospital within 24h of overdose. All tablets ingested over a period of 2 h or less. Accidental or deliberate overdoses are eligible. Overdose of paracetamol alone or mixtures of tablets are eligible.
- •2. Overdose at risk of toxicity: blood paracetamol concentration over ‘200 line’ on nomogram.
- •3. Provision of informed consent.
- •4. Adult (16 years old or above).
排除标准
- •1. Patients that do not have the capacity to consent.
- •2. Patients who are pregnant or breastfeeding.
- •3. Patients who have previously participated in the study.
- •4. Patients who, in the opinion of the responsible clinician/nurse, are unlikely to complete the full course of NAC e.g. expressing wish to self-discharge.
- •5. Patients detained under the Mental Health Act.
- •6. Patients already started on NAC treatment.
- •7. Known overdose of a modified/extended release preparation of paracetamol.
- •8.Patients with known viral hepatitis or HIV.
研究者
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