The effect of exercise on main iron regulator hormone in patients with Beta Thalassemia Intermedia
Not Applicable
- Conditions
- Beta Thalassemia Intermedia.Beta thalassaemia
- Registration Number
- IRCT2015062516211N2
- Lead Sponsor
- Exercise Physiology Research Center,Baqiyatallah University of Medical Sciences Baqiyatallah
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
1-Patients with Beta Thalassemia Intermedia.
2-Irregular blood transfusions or no blood transfusions.
3-Ejection Fraction more than 55%.
4-Pulmonary artery pressure or (PAP) less than of 30 mm Hg.
5-Lack of Hemochromatosis.
6-The absence of fractures in lower limbs.
7-Lack of diabetes.
Exclusion criteria:
1-Regular blood transfusions.
2-Iron overload in the heart.
3-Splenectomized patients.
4-Drugs such as Digoxin and other drugs associated with heart disease.
5-Personal desire, nausea, vomiting and headache during exercise.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hepcidin. Timepoint: Before, immediately after and 3 hours after the intervention. Method of measurement: Blood sample and ELISA method.;Ferritin. Timepoint: Before, immediately after and 3 hours after the intervention. Method of measurement: Blood sample and Photometric method.
- Secondary Outcome Measures
Name Time Method 24-hour dietary recall. Timepoint: 24 hour before primary blood sample. Method of measurement: By 24-hour dietary recall questionnaire.;Blood pressure. Timepoint: Before and after each period of practice. Method of measurement: By manual manometer and according to mm Hg.;RPE or Rate of Perception Effort. Timepoint: Before and after each period of practice. Method of measurement: 20-point Borg questionnaire.