Two-sample FIT-screening: a 4th screening round
Completed
- Conditions
- colorectal cancer, screening, darmkanker
- Registration Number
- NL-OMON20828
- Lead Sponsor
- Erasmus Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 3197
Inclusion Criteria
Average risk persons aged 50-75 years old in the Rotterdam-Rijnmond region. We will invite all persons from the dynamic cohort of approximately 3200 persons that were invited in the previous rounds and were originally recruited by random selection in the city population database (Gemeentelijke Basis Administratie, GBA).
Exclusion Criteria
Exclusion criteria for colonoscopy are: complete colonoscopy or CT-colonography performed within the last 2 years; severe co-morbidity (ASA IV/V); terminal disease (life-expectancy < 5 years); inability or refusal to provide informed consent.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Participation, positivity rate, diagnostic yield of two-sample FIT screening.
- Secondary Outcome Measures
Name Time Method Participation-rate and diagnostic yield of a 4th round of biennial two-sample FIT-screening compared to previous rounds. Impact of repeated biennial two-sample FIT-screening on participation-rates (per round, in consecutive rounds and per program), as well as the yield and occurrence of interval cancers in participants and non-participants of repeated rounds. Comparison of outcomes with paralell one-sample FIT screening cohort.