Effect of the Pneumoperitoneum on Dynamic Variables Delta PP and PVI During Trendelenburg Position.
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Pulse Pressure variation (deltaPP) (in %)
研究概览
简要总结
Arterial pulse pressure variation induced by mechanical ventilation (ΔPP) is considered one of the best parameter to predict fluid responsiveness in patients under general anaesthesia. Pleth Variability Index (PVI) has been proposed as a less invasive alternative. However, the pneumoperitoneum has been recently seen suggested as a limitation to their interpretation. The aim of this observational study is to compare changes in ΔPP and PVI related to autotransfusion associated with a Trendelenburg manoeuver before and during laparoscopy in patients undergoing elective surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) score I-II
- •scheduled for elective abdominal laparoscopic surgery
- •with written informed consent
- •more than 18 years
- •Body Mass Index < 40 kg.m-2
- •no supraventricular arrhythmias
- •no heart failure with ejection fraction <25 %
- •no peripheral vascular
- •no severe respiratory disease
- •no end stage renal failure (creatinine clearance <30ml/min).
排除标准
- 未提供
研究组 & 干预措施
Cohort
Only one cohort is included with comparisons of two different hemodynamic parameters
干预措施: PVI and deltaPP after trendelenburg position change (Device)
结局指标
主要结局
Pulse Pressure variation (deltaPP) (in %)
时间窗: 5 minutes
Before/after trendelenburg positioning in laparoscopic surgery
Pleth variability index (in %)
时间窗: 5 minutes
Before/after trendelenburg positioning in laparoscopic surgery
次要结局
未报告次要终点
研究者
Forget Patrice
PI
Université Catholique de Louvain