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Clinical Trials/NCT00832312
NCT00832312
Terminated
Phase 2

Intraarticular Ozone Therapy for Pain Control in Osteoarthritis of the Knee

Ben-Gurion University of the Negev1 site in 1 country20 target enrollmentAugust 2009

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
Osteoarthritis of the Knee
Sponsor
Ben-Gurion University of the Negev
Enrollment
20
Locations
1
Primary Endpoint
Pain control
Status
Terminated
Last Updated
9 years ago

Overview

Brief Summary

The purpose of this study is to determine whether an intraarticular injection of Ozone into the knee joint is an effective therapy for pain control in patients with osteoarthritis of the knee.

Detailed Description

Ozone, as a gas made of three atoms of oxygen with a cyclic structure, has been used as a medical therapy from the mid ninetieth century. Today, this therapy is a recognized modality in many European and Latin American nations for orthopedic problems, infections, ischemic diseases, and skin problems. However, despite of this wide use internationally, there is minimal mention of this treatment modality in the Anglo-American literature. The present is the first of a series of studies planned to scientifically test the effectiveness of ozone as a main-stream therapy, introducing it to the Anglo-American literature. In this first study we will check whether intraarticular injections of Ozone into the knee joint are effective as a therapy for pain control in patients with osteoarthritis of the knee.

Registry
clinicaltrials.gov
Start Date
August 2009
End Date
August 2016
Last Updated
9 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Howard Tandeter

POB 653 Beer Sheva

Ben-Gurion University of the Negev

Eligibility Criteria

Inclusion Criteria

  • Osteoarthritis of knee

Exclusion Criteria

  • Positive rheumatologic serologic tests
  • Cognitive impairment
  • Adjacent osteomyelitis
  • Bacteremia
  • Hemarthrosis
  • Impending (scheduled within days) joint replacement surgery
  • Infectious arthritis
  • Joint prosthesis
  • Osteochondral fracture
  • Periarticular cellulitis

Outcomes

Primary Outcomes

Pain control

Time Frame: 6 months

Study Sites (1)

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