Impact of the Use of CRP on the Prescription of Antibiotics in General Practitioners
- Conditions
- Respiratory InfectionRespiratory Infections in Children
- Registration Number
- NCT03540706
- Lead Sponsor
- Centre Hospitalier Intercommunal Creteil
- Brief Summary
Respiratory infections, including episodes of coughing with fever, are the main cause of outpatient antibiotic prescription, while a minority of them are linked to bacterial infections requiring antibiotic. These prescriptions are often performed by general practitioners. These unnecessary antibiotic contribute to increased bacterial resistance, side effects and unnecessary costs. Campaigns for the correct prescription of antibiotics have had a real but partial or transient success.
C-reactive protein micro-method (POCT-CRP) could help to differentiate between viral and bacterial infections and thus contribute to the proper use of antibiotics. The decrease in prescription of antibiotics is likely to have an even stronger positive impact in countries like France, where prescription is high.
The objective of this study is to evaluate the use of POCT-CRP in the general practitioner's office in case of suspected respiratory infection.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 406
- Age ≥ 3 years
- Clinical suspicion of respiratory infection defined by the presence of at least one respiratory sign among, cough, dyspnea, chest pain and auscultatory abnormality and at least one general sign among fever, sweat, headache, myalgia, impairment of general condition
- Affiliated to a social health insurance
- Signed consent
- Duration of symptoms < 24 hours
- Hospitalization or emergency assessment decision decided from the outset
- Signs of severity before the realization of POCT-CRP
- Patient previously included in the study for the same episode
- Antibiotic therapy within 7 days
- Chronic cough (more than 3 weeks)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Frequency of antibiotic therapy prescribed 10 days with and without POCT-CRP
- Secondary Outcome Measures
Name Time Method Frequency of complementary exam 10 days with and without POCT-CRP
type of complementary exam 10 days with and without POCT-CRP
Proportion of number of patients with delayed antibiotic therapy 10 days with and without POCT-CRP
COVID-19 positive patients 1 day Number of COVID-19 positive patients by diagnostic method (From October 2020)
Frequency of antibiotic therapy prescribed in patients aged from 18 to 64 years old 10 days with and without POCT-CRP
number of prescription following the recommended algorythms 10 days Adequacy between the proposed decision algorithm according to the C-reactive protein assay and the antibiotic prescription
Frequency of antibiotic therapy prescribed in patients aged from 3 to 17 years old 10 days with and without POCT-CRP
Frequency of antibiotic therapy prescribed in patients older than 65 years old 10 days with and without POCT-CRP
Proportion of number of patients referred to emergency 10 days with and without POCT-CRP
Concordance between the prescription proposed by the decision algorithm as a function of the micro-CRP and the prescription realized: kappa coefficient 10 days The assessment of the utility of the POCT procedure
Type of antibiotic prescribed 10 days
Trial Locations
- Locations (14)
22 rue de Silly
🇫🇷Boulogne, France
18 rue Sainte Bathilde
🇫🇷Chelles, France
25 avenue des frères Lumière
🇫🇷Cormeilles-en-Parisis, France
8 Rue Saint-Exupéry
🇫🇷Meudon La Forêt, France
258 Bis Rue de Paris
🇫🇷Montreuil, France
61bis Boulevard de Charonne
🇫🇷Paris, France
25 Rue de Fécamp
🇫🇷Paris, France
237 Rue de la Croix Nivert,
🇫🇷Paris, France
1 Rue Colette Magny
🇫🇷Paris, France
391 Rue des Pyrénées
🇫🇷Paris, France
Scroll for more (4 remaining)22 rue de Silly🇫🇷Boulogne, France