Impact of the Use of C-reactive Protein in a Micro-method on the Prescription of Antibiotics in General Practitioners Consulting in the Office
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 406
- 试验地点
- 28
- 主要终点
- Frequency of antibiotic therapy prescribed
研究概览
简要总结
Respiratory infections, including episodes of coughing with fever, are the main cause of outpatient antibiotic prescription, while a minority of them are linked to bacterial infections requiring antibiotic. These prescriptions are often performed by general practitioners. These unnecessary antibiotic contribute to increased bacterial resistance, side effects and unnecessary costs. Campaigns for the correct prescription of antibiotics have had a real but partial or transient success.
C-reactive protein micro-method (POCT-CRP) could help to differentiate between viral and bacterial infections and thus contribute to the proper use of antibiotics. The decrease in prescription of antibiotics is likely to have an even stronger positive impact in countries like France, where prescription is high.
The objective of this study is to evaluate the use of POCT-CRP in the general practitioner's office in case of suspected respiratory infection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 3 years
- •Clinical suspicion of respiratory infection defined by the presence of at least one respiratory sign among, cough, dyspnea, chest pain and auscultatory abnormality and at least one general sign among fever, sweat, headache, myalgia, impairment of general condition
- •Affiliated to a social health insurance
- •Signed consent
排除标准
- •Duration of symptoms < 24 hours
- •Hospitalization or emergency assessment decision decided from the outset
- •Signs of severity before the realization of POCT-CRP
- •Patient previously included in the study for the same episode
- •Antibiotic therapy within 7 days
- •Chronic cough (more than 3 weeks)
结局指标
主要结局
Frequency of antibiotic therapy prescribed
时间窗: 10 days
with and without POCT-CRP
次要结局
- Frequency of complementary exam(10 days)
- type of complementary exam(10 days)
- Proportion of number of patients with delayed antibiotic therapy(10 days)
- COVID-19 positive patients(1 day)
- Frequency of antibiotic therapy prescribed in patients aged from 18 to 64 years old(10 days)
- number of prescription following the recommended algorythms(10 days)
- Frequency of antibiotic therapy prescribed in patients aged from 3 to 17 years old(10 days)
- Frequency of antibiotic therapy prescribed in patients older than 65 years old(10 days)
- Proportion of number of patients referred to emergency(10 days)
- Concordance between the prescription proposed by the decision algorithm as a function of the micro-CRP and the prescription realized: kappa coefficient(10 days)
- Type of antibiotic prescribed(10 days)