The effect of critical illness on fat absorption: comparative measurements in healthy volunteers
Not Applicable
Completed
- Conditions
- Critical illnessMetabolic and Endocrine - Normal metabolism and endocrine development and function
- Registration Number
- ACTRN12612001077853
- Lead Sponsor
- Dr Yasmine Ali Abdelhamid
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Healthy volunteers aged over 17 years.
Exclusion Criteria
Inability to give informed consent.
Contraindication to naso-duodenal feeding tube placement.
Previous surgery on the oesophagus, stomach or duodenum.
Any gastrointestinal disease.
History of diabetes mellitus.
Pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will be lipid absorption in the healthy population, which can then be compared to the data that the investigators have already obtained in the critically ill, mechanically ventilated population.<br>Lipid absorption is derived from end-expiratory breath samples (10mL) for the measurement of the 13C-Triolein by-product, 13CO2, which will be taken throughout the study.[At baseline, 5, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330 and 360 minutes after the commencement of the infusion.]
- Secondary Outcome Measures
Name Time Method Glucose absorption as derived from the area under the 3-OMG concentration curve, peak concentration and time to peak. This will be measured from venous blood samples(5ml).[At baseline, 5, 15, 30, 45, 60, 90, 120, 150, 180, 240, 300 and 360 minutes after the commencement of the infusion.];Plasma concentration of motilin measured from venous blood samples (4ml).[At baseline, 30 and 240 minutes after the commencement of the infusion.]