Alcohol Metabolism and Disease Risk in Asians: Examining the Impact of Personalized Phenotypic/Genotypic Feedback and Motivational Processes on Early Drinking Trajectories
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 360
- 试验地点
- 2
- 主要终点
- Peak Number of Alcohol Drinks Consumed in a Day
研究概览
简要总结
The primary pathway of alcohol metabolism involves two main enzymes, alcohol and aldehyde dehydrogenase. Several genes that encode these enzymes have variants that alter the rate of alcohol metabolism and increase levels of acetaldehyde. The variant ALDH2*2 allele is associated with the flushing response (i.e., Asian glow) and is found almost exclusively in individuals of east Asian descent. Although having variant ALDH2 alleles is protective against heavy drinking and alcohol use disorders, for those who do drink, these variants also are associated with elevations in risk for several health problems. The premise of this study is that we can affect early drinking behavior through personalized communication about these health-related risks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 17 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All participants will be of Asian heritage (i.e. Chinese/Taiwanese, Japanese, Korean, Vietnamese).
- •About half of the sample will be incoming first-year undergraduates
- •About half of the sample will be current undergraduates who self-report having flushed when they first started drinking alcohol
排除标准
- 未提供
结局指标
主要结局
Peak Number of Alcohol Drinks Consumed in a Day
时间窗: Baseline through 10-months post-intervention (which occurred on 1 day)
Drinking quantity (i.e. total number of alcoholic drinks) consumed on heaviest drinking day
次要结局
- Number of Drinking Days(Baseline through 10-months post-intervention (which occurred on 1 day))
- Number of Alcoholic Drinks Consumed on Weekend(Baseline through 10-months post-intervention (which occurred on 1 day))
- Number of Alcoholic Drinks Consumed Weekly(Baseline through 10-months post-intervention (which occurred on 1 day))
- Number of Participants Identified as Non-drinkers(Baseline through 10-months post-intervention (which occurred on 1 day))
- Alcohol Flush Cure Use Rate(Baseline through 10-months post-intervention (which occurred on 1 day))
研究者
Susan Luczak
Professor (Research)
University of Southern California