NCT01122797已完成不适用
Study of Metabolism Influence in Human Alcoholic Liver Disease
Erasme University Hospital1 个研究点 分布在 1 个国家目标入组 658 人开始时间: 2003年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 658
- 试验地点
- 1
- 主要终点
- Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.
研究概览
简要总结
Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Excess alcohol intake
- •Abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or a suspicion of cirrhosis related to ALD
- •Caucasian ethnicity
排除标准
- •Presence of any other chronic liver disease
- •Co-infection with human immunodeficiency virus
- •Inclusion Criteria:
- •Caucasian ethnicity
- •Exclusion Criteria:
- •Presence of a disease
结局指标
主要结局
Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.
After liver histology assessment for liver liver dammage a potential correlation of fibrosis and steatosis was studied with rs738409 PNPLA3 polymorphism
次要结局
未报告次要终点
研究者
研究点 (1)
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