A Cohort Study on the Efficacy of Bariatric Surgery for Rapidly Progressing Diabetic Nephropathy
Recruiting
- Conditions
- Bariatric SurgeriesDiabetic Nephropathy
- Registration Number
- NCT06661174
- Lead Sponsor
- China-Japan Friendship Hospital
- Brief Summary
Establish a cohort of diabetic kidney disease(DKD) patients with intensive weight loss treatment to evaluate the impact of intensive weight loss treatment on the renal prognosis of DKD and construct a prediction model for the improvement of renal outcomes after weight loss.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
-
Age 18 to 65 years old;
-
BMI>25Kg/m2 or abdominal obesity (i.e. waist circumference>90cm for men and>85cm for women);
- eGFR<30ml/min/1.73m2 or urinary microalbumin≥300mg/g, eGFR<60ml/min/1.73m2.
-
Exclusion Criteria
-
Patients who are taking glucocorticoids;
- Combined with tumors; ③Combined with autoimmune diseases; ④Serum albumin<25g/L.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total weight loss 1st, 3rd, 6th and 12th month after intervention, respectively.
- Secondary Outcome Measures
Name Time Method Serum creatinine 1st, 3rd, 6th and 12th month after intervention, respectively. Glomerular filtration rate 1st, 3rd, 6th and 12th month after intervention, respectively. Fasting blood glucose 1st, 3rd, 6th and 12th month after intervention, respectively. Average blood glucose from continuous glucose monitoring 1st, 3rd, 6th and 12th month after intervention, respectively. Postprandial 2-hour blood glucose 1st, 3rd, 6th and 12th month after intervention, respectively. HbA1c 1st, 3rd, 6th and 12th month after intervention, respectively. Waist circumference and hip circumference 1st, 3rd, 6th and 12th month after intervention, respectively. Urinary microalbumin and other Urinalysis indexes 1st, 3rd, 6th and 12th month after intervention, respectively. Medication status 1st, 3rd, 6th and 12th month after intervention, respectively.
Trial Locations
- Locations (1)
China-Japan Friendship Hospital
🇨🇳Beijing, Beijing, China
China-Japan Friendship Hospital🇨🇳Beijing, Beijing, China