Effect of a standard oral salt loading test on the renin-angiotensin-aldosterone system in healthy subjects - assessment of reference values

Recruiting

• Conditions: adrenal hypertension; primary aldosteronism; 10001353

• Registration Number: NL-OMON39385
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 26 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

healthy male and female subjects with a normal blood pressure (RR < 140/90 mmHg)

Exclusion Criteria

- hypertension (RR>140/90mmHg)
- past medical history of heart failure
- elevated liver enzymes (ALAT, ASAT, gGT, AF > 1.5 URL)
- renal insufficiency (serum creatinine > 110 micrmol/l)
- diabetes mellitus (any type)
- pregnancy
- use of specific drugs: antihypertensives, nonsteroidal anti-inflammatory drugs, diuretics, potassium supplements

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in renin-angiotensin-aldosterone system (RAAS) after an oral salt<br /><br>loading test. The following RAAS parameters will be measured: plasma renin<br /><br>concentration, plasma renin activity, serum aldosterone, urinary aldosterone<br /><br>(free + metabolites)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Influence of OC's on previously described RAAS parameters before and after salt<br /><br>loading.</p><br>