Evaluation of the Effects of Oxygen Therapy and Enalapril for Diabetic Macular Ischemia
- Registration Number
- NCT00899587
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
In this study, patients were divided into 3 group with 35 cases including: 1.oxygen 2.enalapril 3.control.
In the beginning of the study, best corrected visual acuity (BCVA), uncorrected visual acuity (UCVA), and optical coherence tomography (OCT) were measured. Patients in the oxygen group were given oxygen 10 lit/min 1 hour twice a day at the first month, once a day at the second month and every other day at the third month. In the enalapril group, patients were given enalapril 5 mg every night and placebo was given for the patients in third group. At the end of first month the patients' vision was checked again and at the the end of the third month the first physical examinations were performed. In the first group, arterial blood gas (ABG) was taken before and after oxygen therapy as well.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
- Patients diagnosed with diabetic macular ischemia
- HTN > 1140/90 or HTN controlled by ACE inhibitors
- FBS > 200
- Severe anemia, COPD, cataract, HRPDR and diffuse macular edema
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Control placebo - Oxygen oxygen - Enalapril enalapril -
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ophthalmic Research Center
🇮🇷Tehran, Iran, Islamic Republic of