Cerebral Oxygenation and Circulatory Parameters During Pressure Controlled vs. Volume Targeted Mechanical Ventilation in the Extremely Preterm Infants With Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Stroke volume variation (SVV)
研究概览
简要总结
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
详细描述
Prospective, cross-over trial enrolling neonates <28 weeks' gestation requiring MV. Patients were ventilated for 3 hours with pressure controlled assist-control (PC-AC) mode, followed by 3-hours of volume guarantee assist-control ventilation (VG-AC). Continuous monitoring was carried out using pulse oximetry (oxygen saturation - SpO2 and heart rate - HR), near-infrared spectroscopy (cerebral oxygenation - StO2) and electrical cardiometry (circulatory parameters).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 24 Weeks 至 27 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •premature infants born <28 weeks of gestation
- •respiratory failure in the course of respiratory distress syndrome requiring mechanical ventilation
- •stable condition with pH (acidity of blood)> 7.2 and pCO2 (carbon dioxide partial pressure) <60 mmHg in the blood gas analysis
- •no identified genetic syndromes and serious congenital malformations
排除标准
- •lack of written consent of patients' parents
结局指标
主要结局
Stroke volume variation (SVV)
时间窗: 6 hours
Stroke volume variation (SVV) monitored with electrical cardiometry \[percent\]
Index of contractility
时间窗: 6 hours
Index of contractility (ICON) monitored with electrical cardiometry
Stroke volume
时间窗: 6 hours
Stroke volume (SV) monitored with electrical cardiometry \[ml\]
Cardiac output
时间窗: 6 hours
Cardiac output (CO) monitored with electrical cardiometry \[L/min\]
Stroke index
时间窗: 6 hours
Stroke index (SI) monitored with electrical cardiometry \[ml/m2\]
Cardiac index
时间窗: 6 hours
Cardiac index (CI) monitored with electrical cardiometry \[L/min/m2\]
StO2
时间窗: 6 hours
Cerebral oxygenation measured using near-infrared spectroscopy \[percent\]
次要结局
未报告次要终点