Comparison of ketamine-dexmedetomidine nebulisation versus intravenous route for awake fibreoptic intubatio
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: 3- Administration
- Registration Number
- CTRI/2020/11/029005
- Lead Sponsor
- Chaitra
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Pateints giving written informed consent will be taken.
2. Aged between 18-60years of both sex with ASA physical status I and II.
3. Patients with anticipated difficult airway undergoing elective surgical
procedures.
Exclusion Criteria
Any type of A-V block on electrocardiogram (ECG), heart failure, coronary heart disaese.
liver cirrhosis, thrombocytopenia and coagulopathies
severe bradycardia
current psychiatric disorder, history of seizures
any respiratory disorders
history of epistaxis, nasal pathology
known drug allergy to the study drugs
ASA III and ASA IV
pregnant female
Emergency procedures
Patient refusal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time required for intubation between group receiving dexmedetomidine+ketamine through intravenous route and group receiving dexmedetomidine+ketamine through nebulisation. <br/ ><br>Timepoint: Time required for intubation is calculated when first reading obtained by capnograph after <br/ ><br> entotracheal intubation. That is after 10mins of baseline till first capnograph reading. <br/ ><br>
- Secondary Outcome Measures
Name Time Method adverse eventsTimepoint: postoperative period;cough severityTimepoint: while passing the fibreoptic bronchoscope;ease of intubationTimepoint: while passing the endotracheal tube through vocal cords;hemodynamic changes (HR,SBP,DBP,MAP,ECG,SPO2)Timepoint: baseline,2mins,4mins,6mins,8mins,10mins,fibreoptic through nostril,ETT through nasopharynx,ETT through glottis,5mins after intubation and 10mins after intubation;patient toleranceTimepoint: whicle performing the procedure;recall of events and discomfort during procedureTimepoint: postoperative period;the sedation scoreTimepoint: at the end of trial drug administration