Preoperative predictors of weight loss and improved metabolic health after bariatric surgery - Predictors of weight loss and metabolic health after bariatric surgery

Endocrinologie&metabolisme0 个研究点目标入组 1,200 人开始时间: 待定最近更新: 2024年6月18日

适应症

试验速览

暂无简介。

•* Ability to provide informed consent
•* Patient is >= 18 and <= 75 years old
•* BMI >= 40 kg/m2 or >= 35 kg/m2 with obesity related comorbidity
•* Scheduled for primary bariatric procedure: Roux-en-Y gastric bypass (RYGB) or
•Sleeve Gastrectomy (SG)
•* Stable weight 3 months prior to inclusion weight (<10% change in body weight
•for 3 months prior to assessments)
•In order to be eligible to participate in the subgroup of this study, we will
•use the following inclusion criteria:
•* We will include only patients who will undergo RYGB;
•* Patients who are insulin resistant (impaired fasting glucose (> 5.6 mmol/L)
•or fasting insulin > 74 pmol/L)
•* Postmenopausal women (to prevent bias due to the effect of sex homones on
•insulin sensitivity)

•A potential subject who meets any of the following criteria will be excluded
•from participation in this study:
•* Patients who do not understand the patient information letter
•* Any actual medical condition except for obesity related health issues or well
•treated hypothyroidism
•* Pregnancy anticipated in the first two years following surgery
•A potential subject who meet the following criteria will be excluded from
•participation in the subgroup of this study:
•* Coagulation disorders and/or use anticoagulants
•* Use of any medication except for statins, antihypertensives (except for ACE-
•or angiotensin receptor blockers) and thyroid hormone
•* Diabetes mellitus type 2

发起方

Endocrinologie&metabolisme