Evaluation of the Deep TMS H-Coil in the Treatment of Major Depression- Augmentation of Antidepressant Medication
Phase 1
Completed
- Conditions
- Major Depression
- Registration Number
- NCT00460902
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
Evaluation of the novel deep TMS H-Coil design as an augmentation measure in the treatment of medication resistant major depression. Stimulation is administered with and without cognitive-emotional provocation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 57
Inclusion Criteria
- Patients diagnosed as suffering from treatment resistant major depression
- Right laterality
Exclusion Criteria
- other major axis I diagnosis
- severe axis II diagnosis
- risk factors to convulsions
- history of drug abuse in the past year
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method HAMILTON RATING SCALE FOR DEPRESSION 24 items 4 weeks
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the deep TMS H-Coil's efficacy in augmenting antidepressant therapy for drug-resistant depression?
How does the H-Coil TMS device compare to conventional TMS and ECT in treating medication-resistant major depressive disorder?
Which biomarkers correlate with response to H-Coil TMS augmentation in patients with treatment-resistant depression (TRD)?
What adverse events are associated with deep TMS H-Coil treatment in phase 1 trials for major depressive disorder?
Are there synergistic effects when combining H-Coil TMS with SSRIs or SNRIs in drug-resistant depression treatment protocols?
Trial Locations
- Locations (2)
Beer Yaacov Medical Center
🇮🇱Beer Yaacov, Israel
Biological psychiatry unit, Psychiatric ward, Hadassah Medical organization
🇮🇱Jerusalem, Israel
Beer Yaacov Medical Center🇮🇱Beer Yaacov, Israel