The effect of herbal mouthwash on oral mucositis in children with leukemia under chemotherapy

Phase 3

Recruiting

Conditions: oral chemotherapy for leukemia in children with leukemia.
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
C81-C96

Registration Number: IRCT20200222046582N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Completion of written consent by the child or the child's guardian parent (based on the child's age) for the child's participation in the study
Having a child has the necessary ability and cooperation to participate in the study
Lack of systemic problems (kidney, liver, etc.) or other malignancies
Food allergies or known allergies to aloe vera
Lack of diabetes and no history of hyperglycemia
The child has oral health before starting chemotherapy (no mucositis)
Do not use other mouthwashes during treatment, do not use painkillers continuously, do not use antibiotics

Exclusion Criteria

Children undergoing radiotherapy in addition to chemotherapy
Children who refuse to continue their studies
Patients with neutropenia, fever, gingivitis
Teens who smoke and smoke hookah
Use of steroidal anti-inflammatory drugs

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
During the first, seventh, fourteenth, twenty-first days after chemotherapy with the help of a researcher examining inflammation of the oral mucosa using the Ilers tool and the oral cavity condition using the WHO tool, aswell as the pain caused by mucositis (by the child) using the VAS tool And the question of the child who has experienced the most pain during the day? All 4 groups under study will be reviewed and recorded. Timepoint: During the first, seventh, fourteenth and twenty-first days after chemotherapy. Method of measurement: With the help of a researcher examining inflammation of the oral mucosa using the Ilers tool and the oral cavity condition using the WHO moucositis scale tool, as well as pain caused by mucositis (by the child) using the tool and Visual Analogue Scale ask the child which pain is most common during the day. Experienced? All 4 groups under study will be reviewed and recorded.

Secondary Outcome Measures