Time to post-operative recovery of Serum Albumin as a predictor of outcome in Major Hepato Pancreato Biliary Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- To correlate Time to reversal trend of albumin as a predictor of outcome in major HPB surgeries as measured by hospital stay.
研究概览
简要总结
Hepatobiliary and Pancreatic surgery is associated with substantial risk of postoperative complications. Albumin is a negative acute phase protein. Its rapid decline may be due to degree of inflammation due to surgical procedures. The decline may due to multifactorial causes.Currently, contemporary data regarding the time to recovery of albumin, as a marker for early recovery of patient from surgical stress is sparse. Delta albumin is influenced by perioperative fluid administration and albumin supplementation. Delta albumin may not reflect the true surgical stress. Early post op albumin is a reflection of intraoperative events and not postoperative recovery or events and is unpredictable. Shorter recovery time of albumin is associated with less post op complications and hospital stay. Earlier recovery of albumin predicts lower morbidity and shorter hospital stay.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 13.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients undergoing major Hepato pancreatico Biliary surgeries. Patients who are more than 12 years of age Retrospective arm.
- •Data from 2011.
排除标准
- •Patients who refuse or are unable to give consent.
- •Patients with Nephrotic syndrome, Protein losing enteropathies, Inflammatory bowel Disease, Cirrhosis Emergency Surgeries Data unavailable in retrospective arm Patients who underwent Discharge against Medical advice and who had in hospital mortality.
结局指标
主要结局
To correlate Time to reversal trend of albumin as a predictor of outcome in major HPB surgeries as measured by hospital stay.
时间窗: 30 days
次要结局
- To correlate the time to recovery of albumin with hospital stay complications & morbidity (Clavien Dindo classification Comprehensive Complication Index Intensive Care Unit Stay)(Time to reversal trend of albumin & CCI)
研究者
Rajagopalan G
Institute of Liver and Biliary Sciences