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Clinical Trials/NCT03258775
NCT03258775
Completed
Not Applicable

Water Consumption, Hydration and Resting Energy Expenditure

George Mason University0 sites16 target enrollmentOctober 1, 2015

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Hydration and Resting Metabolism
Sponsor
George Mason University
Enrollment
16
Primary Endpoint
Resting Metabolic Rate (RMR)
Status
Completed
Last Updated
8 years ago

Overview

Brief Summary

A randomized, cross over study will assess the effects of ingestion of high and low volumes of water on REE over 90 minutes. The high volume of water 500ml and the low volume of water 250ml. Participants will be computer randomized to determine which volume of water to receive first. Participants will arrive at the Nutrition Assessment Laboratory between 7:00 and 7:30am following a 9 hour overnight fast. Participants will be instructed not to consume any food or drink after 10pm the night before the assessment. Participants will also be asked to abstain from alcohol and caffeine for 3 days before the assessment. After verification of eligibility, baseline REE will be measured for 30 minutes followed by administration of first assigned dose of water. REE will be monitored for the next 90 minutes. Blood pressure and heart rate will also be monitored, simultaneously to REE. After a 7-10 day washout period, participants will return for their second test day where the second dose of water will be administered. A 7-10 day washout period was selected to allow participants time to resume normal diet and hydration between visits.

Registry
clinicaltrials.gov
Start Date
October 1, 2015
End Date
August 1, 2016
Last Updated
8 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • 18-39 years of age
  • Generally Healthy men and women
  • BMI 18.5-28
  • Willing to abstain from caffeine for 3 days prior to testing
  • Able to provide written consent in English
  • Ability to communicate in English (oral and written

Exclusion Criteria

  • \<18 or \>39 years
  • BMI \< 18.5 or \>28
  • Pregnant or Nursing
  • Taking prescribed or over the counter medication affecting fluid balance or metabolism
  • Suffers from hepatic, renal, pulmonary, endocrine or hematological disease
  • Performs more than 3 hours a week of strenuous exercise
  • Consumes, on average, more than 2 alcoholic beverages per day
  • More than 5kg of weight change over the past 6 months
  • Claustrophobic

Outcomes

Primary Outcomes

Resting Metabolic Rate (RMR)

Time Frame: 90 minutes

Resting Metabolic Rate after water intake

Substrate oxidation

Time Frame: 90 minutes

Change in substrate oxidation after water intake

Secondary Outcomes

  • blood pressure(90 minutes)
  • heart rate(90 minutes)

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