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临床试验/NCT03258775
NCT03258775已完成不适用

Water Consumption, Hydration and Resting Energy Expenditure

George Mason University0 个研究点目标入组 16 人开始时间: 2015年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
16
主要终点
Resting Metabolic Rate (RMR)

研究概览

简要总结

A randomized, cross over study will assess the effects of ingestion of high and low volumes of water on REE over 90 minutes. The high volume of water 500ml and the low volume of water 250ml. Participants will be computer randomized to determine which volume of water to receive first. Participants will arrive at the Nutrition Assessment Laboratory between 7:00 and 7:30am following a 9 hour overnight fast. Participants will be instructed not to consume any food or drink after 10pm the night before the assessment. Participants will also be asked to abstain from alcohol and caffeine for 3 days before the assessment. After verification of eligibility, baseline REE will be measured for 30 minutes followed by administration of first assigned dose of water. REE will be monitored for the next 90 minutes. Blood pressure and heart rate will also be monitored, simultaneously to REE. After a 7-10 day washout period, participants will return for their second test day where the second dose of water will be administered. A 7-10 day washout period was selected to allow participants time to resume normal diet and hydration between visits.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 39 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • 18-39 years of age
  • Generally Healthy men and women
  • BMI 18.5-28
  • Willing to abstain from caffeine for 3 days prior to testing
  • Able to provide written consent in English
  • Ability to communicate in English (oral and written

排除标准

  • <18 or >39 years
  • BMI < 18.5 or >28
  • Pregnant or Nursing
  • Taking prescribed or over the counter medication affecting fluid balance or metabolism
  • Suffers from hepatic, renal, pulmonary, endocrine or hematological disease
  • Performs more than 3 hours a week of strenuous exercise
  • Consumes, on average, more than 2 alcoholic beverages per day
  • More than 5kg of weight change over the past 6 months
  • Claustrophobic

结局指标

主要结局

Resting Metabolic Rate (RMR)

时间窗: 90 minutes

Resting Metabolic Rate after water intake

Substrate oxidation

时间窗: 90 minutes

Change in substrate oxidation after water intake

次要结局

  • blood pressure(90 minutes)
  • heart rate(90 minutes)

研究者

申办方类型
Other
责任方
Sponsor

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