Investigating the Effects of Increased Water Consumption on Markers of Gut Health, Microbiota, and Executive Function
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Dehydration
- Sponsor
- University of Illinois at Urbana-Champaign
- Enrollment
- 23
- Locations
- 1
- Primary Endpoint
- Fecal microbiota relative abundance
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. Therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.
Detailed Description
A single arm 3-week hydration intervention will be employed where participants increase their water consumption to 2 (F) or 2.5(M) liters per day which is approximately 70% of the AI for daily water consumption. Pre-test and follow-up measures of fecal microbiota, urinary hydration status, cognitive function, circulating markers, and dietary intake will be assessed at baseline and at 3-week follow up via laboratory visits.
Investigators
Naiman Khan
Associate Professor
University of Illinois at Urbana-Champaign
Eligibility Criteria
Inclusion Criteria
- •19-50 years of age
- •18.5-34.49 kg/m2
- •24-hour UOsm above 500 mOsm/kg
- •No antibiotic use over the past 3 months
- •Absence of metabolic diseases and use of diuretics
- •Agree to maintain typical diet intake (e.g., dietary fiber) patterns during intervention
- •Avoid consuming prebiotic and probiotic supplements during study participation
- •Not pregnant
- •Agree to follow the study protocol
Exclusion Criteria
- •\<19 or \>50 years of age
- •\<18.5 or \>34.49 kg/m2
- •24-hour UOsm \<500 mOsm/kg
- •Antibiotic use over the past 3 months
- •Metabolic diseases and use of diuretics
- •Not agree to maintain typical diet intake (e.g., dietary fiber) patterns for the duration of the
- •intervention
- •Not agree with avoiding consuming prebiotic and probiotic supplements during study participation
- •Not agree to follow study protocol
Outcomes
Primary Outcomes
Fecal microbiota relative abundance
Time Frame: 3 weeks (baseline vs. follow-up)
changes in the relative abundance of fecal microbiota
Plasma lipopolysaccharide (LPS)
Time Frame: 3 weeks (baseline vs. follow-up)
changes in circulating LPS
Secondary Outcomes
- Attentional accuracy(3 weeks (baseline vs. follow-up))
- Attentional Reaction Time(3 weeks (baseline vs. follow-up))
- 24hr Urine Osmolality(3 weeks (baseline vs. follow-up))
- Copeptin(3 weeks (baseline vs. follow-up))
- Attentional processing speed(3 weeks (baseline vs. follow-up))
- 24hr Urine Specific Gravity(3 weeks (baseline vs. follow-up))