Inflammatory changes following a dietary intervention in the elderly.

Not Applicable

Completed

• Conditions: Inflammation; Inflammatory and Immune System - Normal development and function of the immune system

• Registration Number: ACTRN12611000619943
• Lead Sponsor: Jessica Grieger

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Men and women >64 years old
- Fish/seafood intake <1 serving of fish/week
- Willing to consume ~4 servings of provided fish/seafood per week OR red meat per week
- Ability to provide written informed consent
- Able to attend clinic visits at Flinders Medical Centre

Exclusion Criteria

- Inability to comply with study protocol
- Allergies to seafood
- Vegetarian
- Intake of vitamin and mineral supplements within the past 3 weeks of clinic screening
- Intake of lipid-lowering supplements (eg. psyllium, fish oil capsules, soy lecithin, phytoestrogens)
- Intake of anti-inflammatory medications on a regular basis or if an acute intake, within 1 week of clinic screening visit
- On warfarin medication
- Presence of diabetes, liver, kidney, thyroid (unless controlled and stable on replacement medication)
- Presence of other endocrine disorders from self-reported medical history
- Weight loss or gain of 10% body weight or more during a period of 6 months before screening visit
- Clinically diagnosed depression or dementia.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma CRP[Baseline and end of study (ie. week 0 and week 8)];Red blood cell fatty acids[Baseline and end of study (ie. week 0 and week 8)]

Secondary Outcome Measures

Name	Time	Method
Clinical: Blood pressure, plasma lipids (TC, Triglycerides, HDL-C, LDL-C, glucose)[Baseline and end of study (ie. week 0 and week 8)];Centre for Epidemiologic Studies-Depression Scale[Baseline and end of study (ie. week 0 and week 8)];Inflammatory markers/cytokines: Plasma IL-6, IL-1, TNF-alpha, ICAM-1, VCAM-1, E-selectin[Baseline and end of study (ie. week 0 and week 8)];Body composition: DXA[Baseline and end of study (ie. week 0 and week 8)]